MK-677 – How Much Does It Increase Growth Hormone?

Optimised Research Labs (ORL) MK-677 (Ibutamoren) from Discounted SARMs is considered a Smart SARM for its ability to significantly elevate growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels without the need for injections. But how much does Optimised Research Labs MK-677 really increase growth hormone, according to research?

Understanding MK-677 (Ibutamoren)

MK-677 is an orally active, non-peptide compound that mimics the action of ghrelin, binding to the ghrelin receptor (GHSR) in the brain. This triggers the release of growth hormone from the pituitary gland, leading to elevated circulating GH and IGF-1 levels [1]. As a Smart SARM, Optimised Research Labs (ORL) MK-677 offers the convenience of oral dosing alongside research-backed effectiveness.

Research on Growth Hormone Increases

Multiple studies have shown that MK-677 can cause substantial increases in GH and IGF-1:

  • Daily dosing of 25 mg: In a 2-month clinical study, healthy adults taking MK-677 experienced a ~60% increase in serum GH levels within the first week, sustained throughout the trial [2].
  • Long-term effects: A 12-month study in older adults showed that MK-677 elevated IGF-1 levels by approximately 40% and maintained higher baseline GH secretion over the course of the year [3].
  • Consistency across populations: Whether in young adults or elderly participants, MK-677 has been shown to produce GH increases comparable to daily injectable growth hormone therapy [4].

Benefits of Higher Growth Hormone Levels

Increased GH and IGF-1 can support:

  • Muscle growth and recovery
  • Improved fat metabolism
  • Better skin elasticity
  • Enhanced bone density
  • Deeper, more restorative sleep

Conclusion

Research consistently shows that Optimised Research Labs (ORL) MK-677 from Discounted SARMs, regarded as a Smart SARM, can significantly elevate growth hormone and IGF-1 levels — often by 40–60% or more, depending on dosage and duration. This makes it a highly effective oral option for those seeking the benefits of increased GH without the inconvenience of injections.

References

  1. Smith, R. G. et al. (1997). MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. Journal of Clinical Endocrinology & Metabolism, 82(2), 565–573.
  2. Murphy, M. G. et al. (1998). Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. Journal of Bone and Mineral Research, 13(8), 1183–1188.
  3. Chapman, I. M. et al. (2001). The effect of MK-677, a growth hormone secretagogue, on body composition and clinical outcomes in healthy elderly adults: a randomized controlled trial. Annals of Internal Medicine, 135(6), 433–441.
  4. Nass, R. et al. (2008). Oral administration of the growth hormone secretagogue MK-677 increases fat-free mass in obese males. Journal of Clinical Endocrinology & Metabolism, 93(2), 481–488.
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